Also known as the Great Wars of Italy, they mostly are the result of the claim of four French Kings, from Charles VIII to Henri II, on the Kingdom of Naples and the Duchy of Milan. They first begin as confrontations between France, Spain, England, Holy Roman Empire and the Papal States but rapidly transformed in 1521 into a confrontation between the dynasties of the Habsburgs and the Valois after Charles Quint’s election as Emperor. The Italian Wars are known for 2 major events: the battle of Marignan, in 1515 and the Sack of Rome, in 1527.